IGF-LR3 (Insulin-Like Growth Factor 1 Long R3) – Research Peptide
IGF-LR3 is a synthetic 83-amino acid analogue of IGF-1 engineered with an Arg(R) substitution at position 3 and an N-terminal extension. This structural modification dramatically reduces binding to IGF-binding proteins (IGFBPs), substantially extending its effective half-life compared to native IGF-1.
Research Context
IGF-LR3 activates the IGF-1 receptor, triggering PI3K/Akt and MAPK signaling cascades. It is used in research examining cell proliferation, differentiation, protein synthesis, anti-apoptotic signaling, and muscle biology without requiring prior GH pathway activation.
Properties
- Class: IGF-1 analogue (Long R3 variant)
- Amino acids: 83
- Form: Lyophilized powder
- Purity: ≥98% (HPLC verified)
- Quantity: 0.1mg per vial
Storage & Handling
Store at -20°C. Reconstitute with sterile acetic acid or bacteriostatic water per laboratory protocol. Refrigerate after reconstitution and aliquot to avoid freeze-thaw cycles.
Disclaimer: This product is strictly intended for in vitro laboratory research purposes only. Not for human or veterinary use.
